# cumulative\_scaffold\_frequency\_plot

**URL:** <https://forum.knime.com/t/cumulative-scaffold-frequency-plot/25648>\
**Category:** KCH Workflows\
**Created:** [August 4, 2020, 1:43am UTC](https://forum.knime.com/t/cumulative-scaffold-frequency-plot/25648 "2020-08-04T01:43:08Z")\
**Posts on this page:** 6\
**Page:** 1

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**Author:** ![Hub](https://forum-cdn.knime.com/user_avatar/forum.knime.com/hub/32/5438_2.png) [@Hub](https://forum.knime.com/u/Hub)\
**Post date:** [August 4, 2020, 1:43am UTC](https://forum.knime.com/t/cumulative-scaffold-frequency-plot/25648/1 "2020-08-04T01:43:08Z")

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KNIME AG, Zurich, Switzerland

Version 4.1.1 or later

* * *
This is a companion discussion topic for the original entry at [https://kni.me/w/l9M\_106iXI6NE\_U0](https://kni.me/w/l9M_106iXI6NE_U0)

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**Author:** ![scapuzzi](https://forum-cdn.knime.com/letter_avatar_proxy/v4/letter/s/ecc23a/32.png) [@scapuzzi](https://forum.knime.com/u/scapuzzi)\
**Post date:** [August 4, 2020, 1:45am UTC](https://forum.knime.com/t/cumulative-scaffold-frequency-plot/25648/2 "2020-08-04T01:45:24Z")

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Cumulative scaffold frequency plots are a method to calculate and visualize chemical diversity.

If you find this workflow useful, please cite the original publication:

> **[Scaffold Diversity of Exemplified Medicinal Chemistry Space](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180201/#:~:text=Cumulative%20Scaffold%20Frequency%20Plots%20)**
>
> The scaffold diversity of 7 representative commercial and proprietary compound libraries is explored for the first time using both Murcko frameworks and Scaffold Trees. We show that Level 1 of the Scaffold Tree is useful for the characterization of...

Cheers,  
SC

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**Author:** ![ipazin](https://forum-cdn.knime.com/user_avatar/forum.knime.com/ipazin/32/806_2.png) [@ipazin](https://forum.knime.com/u/ipazin)\
**Post date:** [August 5, 2020, 9:15am UTC](https://forum.knime.com/t/cumulative-scaffold-frequency-plot/25648/3 "2020-08-05T09:15:22Z")

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Hi @scapuzzi,

have seen you commenting on your own workflows with additional information about it. I suggest you adding this information to workflow description. There you can add title, desc, tags, links which is then nicely visible and easier to find on KNIME Hub 😉

 ![WorkflowDesc](https://forum-cdn.knime.com/uploads/default/original/3X/7/5/754f02d89e218bbf22e8b156e7629abcb490a50a.png)

Br,  
Ivan

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**Author:** ![scapuzzi](https://forum-cdn.knime.com/letter_avatar_proxy/v4/letter/s/ecc23a/32.png) [@scapuzzi](https://forum.knime.com/u/scapuzzi)\
**Post date:** [August 5, 2020, 2:01pm UTC](https://forum.knime.com/t/cumulative-scaffold-frequency-plot/25648/4 "2020-08-05T14:01:51Z")

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thanks @ipazin. I am new to sharing on the hub - I appreciate the tip.

PS: do you know how to color and add icons to components?

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**Author:** ![ScottF](https://forum-cdn.knime.com/user_avatar/forum.knime.com/scottf/32/61316_2.png) [@ScottF](https://forum.knime.com/u/ScottF)\
**Post date:** [August 5, 2020, 5:44pm UTC](https://forum.knime.com/t/cumulative-scaffold-frequency-plot/25648/5 "2020-08-05T17:44:58Z")

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Hi @scapuzzi -

You may find this gif helpful - we introduced this feature in KNIME 4.1.

 ![knime_analytics_platform_whatsnew_41_component_editor](https://forum-cdn.knime.com/uploads/default/original/3X/e/8/e8d88e60ca00d897c7ec0a20829a34a38034b7f3.gif)

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**Author:** ![scapuzzi](https://forum-cdn.knime.com/letter_avatar_proxy/v4/letter/s/ecc23a/32.png) [@scapuzzi](https://forum.knime.com/u/scapuzzi)\
**Post date:** [August 5, 2020, 6:19pm UTC](https://forum.knime.com/t/cumulative-scaffold-frequency-plot/25648/6 "2020-08-05T18:19:44Z")

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thanks, @ScottF. this is what i was looking for!