I belive so, its a community extension so you will need to look it up on the community update site or follow the install instructions on the page I linked.
If not you can call the CIR API with the Rest nodes and making the call yourself.
This is the site:
https://cactus.nci.nih.gov/chemical/structure
I’m not 100% clear on what you mean by derivative from the compound. I’m interpreting it to mean something along the lines of an underlining ‘core’ substructure. If so you could maybe look at generating this with something like
Then running the output through a conversion to a format that CIR understands such as smiles.
Hopefully some helpful pointers even though I’m not sure on what it is you’re trying to do.