Out of heap errors reading excel files with 16GB RAM

You can tell each node to store its results on the disc that could save RAM

Managing the flow of data with flow variables is a good idea.

The you could check other tips to increase performance.

The another idea could be to increase the RAM allocated to KNIME to 10 or 12 GB and not have other big programs running.

Then you might give us a better idea how your workflow looks like and what it does so we might see how to improve things.

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