# Physics-Based Membrane Permeability

**URL:** <https://forum.knime.com/t/physics-based-membrane-permeability/26021>\
**Category:** KCH Workflows\
**Created:** [August 11, 2020, 11:23pm UTC](https://forum.knime.com/t/physics-based-membrane-permeability/26021 "2020-08-11T23:23:44Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Hub](https://forum-cdn.knime.com/user_avatar/forum.knime.com/hub/32/5438_2.png) [@Hub](https://forum.knime.com/u/Hub)\
**Post date:** [August 11, 2020, 11:23pm UTC](https://forum.knime.com/t/physics-based-membrane-permeability/26021/1 "2020-08-11T23:23:44Z")

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Calculates an estimated passive membrane permeability for a ligand structure by comparing the energy optimized conformations of that ligand in low and high dielectric. Calculates the amphipilic moment of positively charged molecules.

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This is a companion discussion topic for the original entry at [https://kni.me/w/oceoF7Aaq8QR76lH](https://kni.me/w/oceoF7Aaq8QR76lH)