Two Component Reaction needs equal number of reactants?

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1

Hi,

I'm trying to simulate a Suzuki coupling using the Two Component Reaction node. This works as long as the number of reactants for the 2 reactant ports are the same, but fails if they are unequal (e.g. one bromide to react with a large number of boronic acids):

WARN      RDKit Two Component Reaction       Number of second reactants is lower than number of first reactants.

Seems like a bug to me.

Kind regards,

Evert

2

Make sure you select "Do MAtrix Expansion", otherwise only the reactants on the same row are reacted with each other. 

Simon.

3

Much better, thank you!

Best,

Evert

4

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