Following the announcement of the planned update at the last SIG meeting at the EBI in Hinxton, we have now applied our update to the nightly and stable builds - please use and let us know if you experience any problems!
The update fixes previous memory issues, and also provides much improved performance. An updated description of the new nodes is now available at https://tech.knime.org/book/vernalis-cheminformatics-nodes#MMPs
All original nodes have been deprecated. Users are advised to upgrade workflows to the new equivalent nodes. There are a number of new nodes in the plugin, in addition to the replacements of the legacy nodes.
Also, the nodes are almost all parallelised, and the user can control the number of threads and other options in the preference pages - KNIME-> Vernalis -> Matched Molecular Pairs (MMPs)