$RDFILE 1 $DATM 7/27/2021 17:58:33 $MFMT $MIREG 1 -ISIS- 07272117582D 19 21 0 0 0 0 0 0 0 0999 V2000 0.3542 -2.8167 0.0000 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9667 -2.2625 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6792 -2.6750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4583 -2.6500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6917 -3.5667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3917 -1.4417 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3917 -2.2625 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9667 -1.4292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1125 -1.0292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8292 0.2083 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 1.5167 -3.4792 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6792 -1.0250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0083 -3.2667 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8292 -1.4417 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5417 -1.0375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1125 -0.2042 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2542 -1.4500 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 4.5417 -0.2125 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7125 -1.8667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 0 0 0 3 2 1 0 0 0 0 4 1 1 0 0 0 0 5 1 1 0 0 0 0 6 12 2 0 0 0 0 7 3 2 0 0 0 0 8 2 2 0 0 0 0 9 6 1 0 0 0 0 10 16 1 0 0 0 0 11 5 1 0 0 0 0 12 8 1 0 0 0 0 13 4 2 0 0 0 0 14 9 1 0 0 0 0 15 14 2 0 0 0 0 16 9 2 0 0 0 0 17 15 1 0 0 0 0 18 10 2 0 0 0 0 19 4 1 0 0 0 0 3 11 1 0 0 0 0 6 7 1 0 0 0 0 18 15 1 0 0 0 0 M END $DTYPE MOL:CDBREGNO $DATUM 1 $DTYPE MOL:ID $DATUM ex 1(page 13) $DTYPE MOL:RESULT(1):RECEPTOR $DATUM Cytochrome P450 $DTYPE MOL:RESULT(1):ASSAY $DATUM Aldosterone release assay $DTYPE MOL:RESULT(1):REFERENCE: $DATUM Ali (Merck Sharp and Dohme Corp.), US 9,550,750 B2 $DTYPE MOL:RESULT(1):SOURCE $DATUM Patent $DTYPE MOL:RESULT(1):AFFINITY $DATUM 110 $DTYPE MOL:RESULT(1):YEAR $DATUM 2017 $DTYPE MOL:RESULT(1):FUNCTION $DATUM Inhibitor $DTYPE MOL:RESULT(1):ORGANISM $DATUM Human (V79 cells) $DTYPE MOL:RESULT(1):TYPE $DATUM CYP11B2 $DTYPE MOL:RESULT(1):MEASURE $DATUM IC50 $DTYPE MOL:RESULT(1):UNIT $DATUM nM $DTYPE MOL:RESULT(1):THERAPEUTICDATA $DATUM Alzheimer's disease, rheumatoid arthritis, prostate cancer $DTYPE MOL:RESULT(1):UNIPROTID $DATUM P19099 $DTYPE MOL:RESULT(1):UNIFIEDVALUE $DATUM 1.100000000000000e+002 $DTYPE MOL:RESULT(2):RECEPTOR $DATUM Cytochrome P450 $DTYPE MOL:RESULT(2):ASSAY $DATUM Cortisol production assay $DTYPE MOL:RESULT(2):REFERENCE: $DATUM Ali (Merck Sharp and Dohme Corp.), US 9,550,750 B2 $DTYPE MOL:RESULT(2):SOURCE $DATUM Patent $DTYPE MOL:RESULT(2):AFFINITY $DATUM > 10000 $DTYPE MOL:RESULT(2):YEAR $DATUM 2017 $DTYPE MOL:RESULT(2):ORGANISM $DATUM Human (V79 cells) $DTYPE MOL:RESULT(2):TYPE $DATUM CYP11B1 $DTYPE MOL:RESULT(2):MEASURE $DATUM IC50 $DTYPE MOL:RESULT(2):UNIT $DATUM nM $DTYPE MOL:RESULT(2):UNIPROTID $DATUM P15538 $MFMT $MIREG 2 $RDFILE 1 $DATM 7/27/2021 17:58:33 $MFMT $MIREG 1 -ISIS- 07272117582D 19 21 0 0 0 0 0 0 0 0999 V2000 0.3542 -2.8167 0.0000 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9667 -2.2625 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6792 -2.6750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4583 -2.6500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6917 -3.5667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3917 -1.4417 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3917 -2.2625 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9667 -1.4292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1125 -1.0292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8292 0.2083 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 1.5167 -3.4792 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6792 -1.0250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0083 -3.2667 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8292 -1.4417 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5417 -1.0375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1125 -0.2042 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2542 -1.4500 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 4.5417 -0.2125 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7125 -1.8667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 0 0 0 3 2 1 0 0 0 0 4 1 1 0 0 0 0 5 1 1 0 0 0 0 6 12 2 0 0 0 0 7 3 2 0 0 0 0 8 2 2 0 0 0 0 9 6 1 0 0 0 0 10 16 1 0 0 0 0 11 5 1 0 0 0 0 12 8 1 0 0 0 0 13 4 2 0 0 0 0 14 9 1 0 0 0 0 15 14 2 0 0 0 0 16 9 2 0 0 0 0 17 15 1 0 0 0 0 18 10 2 0 0 0 0 19 4 1 0 0 0 0 3 11 1 0 0 0 0 6 7 1 0 0 0 0 18 15 1 0 0 0 0 M END $DTYPE MOL:CDBREGNO $DATUM 1 $DTYPE MOL:ID $DATUM ex 1(page 13) $DTYPE MOL:RESULT(1):RECEPTOR $DATUM Cytochrome P450 $DTYPE MOL:RESULT(1):ASSAY $DATUM Aldosterone release assay $DTYPE MOL:RESULT(1):REFERENCE: $DATUM Ali (Merck Sharp and Dohme Corp.), US 9,550,750 B2 $DTYPE MOL:RESULT(1):SOURCE $DATUM Patent $DTYPE MOL:RESULT(1):AFFINITY $DATUM 110 $DTYPE MOL:RESULT(1):YEAR $DATUM 2017 $DTYPE MOL:RESULT(1):FUNCTION $DATUM Inhibitor $DTYPE MOL:RESULT(1):ORGANISM $DATUM Human (V79 cells) $DTYPE MOL:RESULT(1):TYPE $DATUM CYP11B2 $DTYPE MOL:RESULT(1):MEASURE $DATUM IC50 $DTYPE MOL:RESULT(1):UNIT $DATUM nM $DTYPE MOL:RESULT(1):THERAPEUTICDATA $DATUM Alzheimer's disease, rheumatoid arthritis, prostate cancer $DTYPE MOL:RESULT(1):UNIPROTID $DATUM P19099 $DTYPE MOL:RESULT(1):UNIFIEDVALUE $DATUM 1.100000000000000e+002 $DTYPE MOL:RESULT(2):RECEPTOR $DATUM Cytochrome P450 $DTYPE MOL:RESULT(2):ASSAY $DATUM Cortisol production assay $DTYPE MOL:RESULT(2):REFERENCE: $DATUM Ali (Merck Sharp and Dohme Corp.), US 9,550,750 B2 $DTYPE MOL:RESULT(2):SOURCE $DATUM Patent $DTYPE MOL:RESULT(2):AFFINITY $DATUM > 10000 $DTYPE MOL:RESULT(2):YEAR $DATUM 2017 $DTYPE MOL:RESULT(2):ORGANISM $DATUM Human (V79 cells) $DTYPE MOL:RESULT(2):TYPE $DATUM CYP11B1 $DTYPE MOL:RESULT(2):MEASURE $DATUM IC50 $DTYPE MOL:RESULT(2):UNIT $DATUM nM $DTYPE MOL:RESULT(2):UNIPROTID $DATUM P15538 $MFMT $MIREG 2 $RDFILE 1 $DATM 7/27/2021 17:58:33 $MFMT $MIREG 1 -ISIS- 07272117582D 19 21 0 0 0 0 0 0 0 0999 V2000 0.3542 -2.8167 0.0000 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9667 -2.2625 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6792 -2.6750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4583 -2.6500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6917 -3.5667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3917 -1.4417 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3917 -2.2625 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9667 -1.4292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1125 -1.0292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8292 0.2083 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 1.5167 -3.4792 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6792 -1.0250 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0083 -3.2667 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8292 -1.4417 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5417 -1.0375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1125 -0.2042 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2542 -1.4500 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 4.5417 -0.2125 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7125 -1.8667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 0 0 0 3 2 1 0 0 0 0 4 1 1 0 0 0 0 5 1 1 0 0 0 0 6 12 2 0 0 0 0 7 3 2 0 0 0 0 8 2 2 0 0 0 0 9 6 1 0 0 0 0 10 16 1 0 0 0 0 11 5 1 0 0 0 0 12 8 1 0 0 0 0 13 4 2 0 0 0 0 14 9 1 0 0 0 0 15 14 2 0 0 0 0 16 9 2 0 0 0 0 17 15 1 0 0 0 0 18 10 2 0 0 0 0 19 4 1 0 0 0 0 3 11 1 0 0 0 0 6 7 1 0 0 0 0 18 15 1 0 0 0 0 M END $DTYPE MOL:CDBREGNO $DATUM 1 $DTYPE MOL:ID $DATUM ex 1(page 13) $DTYPE MOL:RESULT(1):RECEPTOR $DATUM Cytochrome P450 $DTYPE MOL:RESULT(1):ASSAY $DATUM Aldosterone release assay $DTYPE MOL:RESULT(1):REFERENCE: $DATUM Ali (Merck Sharp and Dohme Corp.), US 9,550,750 B2 $DTYPE MOL:RESULT(1):SOURCE $DATUM Patent $DTYPE MOL:RESULT(1):AFFINITY $DATUM 110 $DTYPE MOL:RESULT(1):YEAR $DATUM 2017 $DTYPE MOL:RESULT(1):FUNCTION $DATUM Inhibitor $DTYPE MOL:RESULT(1):ORGANISM $DATUM Human (V79 cells) $DTYPE MOL:RESULT(1):TYPE $DATUM CYP11B2 $DTYPE MOL:RESULT(1):MEASURE $DATUM IC50 $DTYPE MOL:RESULT(1):UNIT $DATUM nM $DTYPE MOL:RESULT(1):THERAPEUTICDATA $DATUM Alzheimer's disease, rheumatoid arthritis, prostate cancer $DTYPE MOL:RESULT(1):UNIPROTID $DATUM P19099 $DTYPE MOL:RESULT(1):UNIFIEDVALUE $DATUM 1.100000000000000e+002 $DTYPE MOL:RESULT(2):RECEPTOR $DATUM Cytochrome P450 $DTYPE MOL:RESULT(2):ASSAY $DATUM Cortisol production assay $DTYPE MOL:RESULT(2):REFERENCE: $DATUM Ali (Merck Sharp and Dohme Corp.), US 9,550,750 B2 $DTYPE MOL:RESULT(2):SOURCE $DATUM Patent $DTYPE MOL:RESULT(2):AFFINITY $DATUM > 10000 $DTYPE MOL:RESULT(2):YEAR $DATUM 2017 $DTYPE MOL:RESULT(2):ORGANISM $DATUM Human (V79 cells) $DTYPE MOL:RESULT(2):TYPE $DATUM CYP11B1 $DTYPE MOL:RESULT(2):MEASURE $DATUM IC50 $DTYPE MOL:RESULT(2):UNIT $DATUM nM $DTYPE MOL:RESULT(2):UNIPROTID $DATUM P15538 $MFMT $MIREG 2