For anyone stumbling upon this issue:
In case you are using Fedora it helps to set the selinux to permissive because from time to time I was running into issues with KNIME itself (It wasn’t finding any updates from time to time for example)
Other than that Perl was failing with my established pipelines because perl modules were missing on my system. Check all your scripts manually within an IDE or a Code Editor of your choice to see which modules are missing.
Unfortunately any possible error coming from Perl regarding missing packages will not be send back to KNIME so you will only receive the error message, that the connection to Perl could not be established.