You can do this with the Rule Engine node. Your formula will look like this:
MISSING $Column2$ => $Column1$
TRUE => $Column2$
This will give you Column 1 if Column 2 is blank… If it’s not blank, it will give you the existing value in Column 2.
You could also probably use the Column Expressions node with the isMissing function to accomplish the same result. Rule engine is probably easiest though.