I have used the Tautomer generator from CDK to generate tautomers for my structures, selecting to keep the best tautomer. The output from this node has no explicit stereocentres, however I need it in order to enumerate stereoisomers. I’ve tried enumerating stereoisomers before generating tautomers, however the best tautomer for both enantiomers are the same.
Thus I was wondering if there was a community node that could identify stereoisomers from a smiles string or sdf file and explicitly mark them, or if there was an alternative tautomer generator out of the community nodes that could do the same thing and maintain chirality.
Thanks
Clinton