Hi @ArakelTheDragon,
Welcome to the Forum! In which way do you want to improve the image? The resolution seems high to me and it does not seem very noisy. Maybe there is some motion blur.
Do you need to improve the image to run some other analysis?
To get rid of the motion blur you would need kernel-blind (and noise-blind) deconvolution. This is very hard to do and an active field of research. There are some forum posts in the image.sc forum about deconvolution: Topics tagged deconvolution.
If this is the only image you want to improve you could maybe get some improvement by sharpening and some other filters (I don’t have much experience with this). KNIME is not the right tool to do this. I would recommend an interactive tool like Fiji/ImageJ or GIMP.