I was working previously on a similar tool (called HiTS) more then a year ago (at Trinity College Dublin). It looks like I will have some time to work on it again (in August or September), but not much, so if you think there is anything that might be useful to update, further develop, adjust to the HCS tools that would be a great help how to know whether you are interested in cooperation and what are your priorities. If you have questions, please ask.
PS.: I no longer work for TCD, so the imaging part will not be updated because the lack of input data. But the data analysis I think might worth updating (biomaRt, cellHTS2) imho.